Smooth the Lines. Rebuild the Collagen.
For visible smoothing, firming, and full-face renewal
Three pharmacy-grade creams targeting collagen, elasticity, and texture — paired with daily inside-out support — for visible firming and smoothing across face, neck, and chest.
"My kids asked if I'd had a facelift thanks to UluRx." — Sara, Verified UluRx Client
One transformation.
What you personalize: Strengths and ingredients in each cream, picked for YOU based on a free 1-min on-site skin quiz — preview your formula before you buy. 👉 Take the 1-Min Skin Quiz See exactly which ingredients go in YOUR custom bundle
Smooth the Lines. Rebuild the Collagen.
AMPLIFY TIER · For visible smoothing, firming, and full-face renewal
"My kids asked if I'd had a facelift thanks to UluRx." — Sara, Verified UluRx Client
What you personalize: Strengths and ingredients in each cream, picked for YOU based on a free 1-min on-site skin quiz — preview your formula before you buy.
Collagen à Trois Transformation System
Your Complete Face Routine for Smoothing Lines, Rebuilding Collagen, and Defending Skin From Within
Three targeted creams for face, neck, and chest—plus daily internal support to keep collagen working for you, not against you.
“My kids asked if I’d had a facelift thanks to UluRx.” — Sara, Real UluRx Client
$449.99 — available on subscription
Doctor and Pharmacist Designed to promote:
Doctor- and pharmacist-designed to support:
- Smoother Lines
- Firmer Skin
- Brighter Tone
- Lifted Look
Product Details
The Collagen à Trois Transformation System is a full‑face anti‑aging plan built around three pharmacy‑grade creams plus the Ulu Ultimate Daily Supplement for inside‑out support. The three prescription-strength creams target collagen renewal and production from three angles, while the supplement adds 40+ ingredients to support healthy skin function, defend against oxidative stress, and boost glow. Together, they create a powerful routine for women who are serious about turning visible aging around—not just slowing it down.
What's Inside
GHK-Cu Copper Peptides 2%
- Starter-strength copper peptide cream for firmer, smoother skin
- Supports collagen, elasticity, and barrier repair without harsh actives
- Layers easily under or over your existing routine for daily use
Key Ingredients
- GHK-Cu Copper Peptides 2% — studied for its role in supporting collagen and elastin, elasticity and firmness.
- Lipo cream base — our proprietary, prescription-grade liposomal base. Paraben-free, lightweight, and engineered to deliver peptides efficiently into the skin.
Estriol Face Cream
- Estrogen-supporting cream designed for mature, hormonally changing skin
- Helps improve skin thickness, firmness, and bounce
- Especially helpful for crepey, paper-thin areas that came on with age
Your Custom Ingredients (personalized)
This Estriol Face Cream is custom-compounded for you. Your provider selects the strengths and any added actives based on your quiz answers — so the exact ingredients in YOUR cream depend on your skin type, age, and goals.
👉 Take the 1-Min Skin Quiz to Preview →Tretinoin Collagen Constructor
- Prescription-strength tretinoin to smooth texture and refine pores
- Supports collagen renewal for firmer, more even skin
- Targets fine lines, sun damage, and overall dullness
Your Custom Ingredients (personalized)
This Tretinoin Collagen Constructor is custom-compounded for you. Your provider selects the strengths and any added actives based on your quiz answers — so the exact ingredients in YOUR cream depend on your skin type, age, and goals.
👉 Take the 1-Min Skin Quiz to Preview →Ulu Ultimate Daily Supplement
- 40+ ingredients: a complete multivitamin plus hair, hormone-support and antioxidant blends
- Supports collagen formation, skin repair, and healthy skin, hair, and nails
- Designed for daily use alongside your topical routine for inside-out results
Who It's For
This system is ideal if you:
See moderate to advanced signs of aging: etched lines, laxity, or crepey patches
Want a prescription‑strength, dermatologist‑style routine without building it product by product
Are in perimenopause, menopause, or post‑menopause and noticing thinner, less resilient skin
Are ready to commit to a structured plan that treats texture, firmness, tone, and overall skin health at the same time
What to Expect
With consistent use, most people notice:
Weeks 2–4: Skin feels smoother and more refined; early glow and softness return as turnover and barrier repair improve.
Weeks 6–8: Fine lines start to soften, tone looks more even, and skin feels bouncier and less “tired.”
Weeks 12+ and beyond: Visible improvement in firmness, deeper wrinkles, and crepey areas, with a healthier, more lifted look overall.
You will receive clear instructions from your provider on how to introduce tretinoin gradually, layer Estriol and Copper Peptides, and take Ultimate Daily every day with food. Consistency and steady use—not overdoing it—are what deliver the best long-term results.
Hear From Our Community
“I’ve been using the GHK-Cu cream in my face for about two weeks and I already see a difference especially on my neck. Am I crazy or does this actually work that fast? … This product is unreal and more women my age should use it!”
“I’m 67 and have been using UluRx Copper Peptides for just 5 weeks. My skin looks amazing, and everyone is asking about my secret. The product is easy to use, and I’ve noticed a significant improvement in my skin’s texture and tone. I feel more youthful and confident. Highly recommend for anyone seeking noticeable results and a confidence boost! Thank you, UluRx, for such incredible skincare products! I’m eternally grateful.” –Sara
“I am on month 2 and let me tell you my skin has never looked this good before! The lines around my mouth and crows feet are disappearing. My skin feels so soft and radiant.” –Diane W., copper peptides client
“I am beyond GRATEFUL for this company and their products. I have been taking the supplements and using the acne Tretinoin script for about a year now, and it has made a world of difference in my skin. I started to get cystic acne after my second child around age 32, and I have been struggling fur the past 7 years. I’ve tried many products and nothing has worked. For me, less is more. My skin’s microbiome needs some help, but too many products only aggravates my skin. I have had my RX adjusted twice now to accommodate changes in my skin needs, and the great thing about this product is that pharmacists customize it for me :-) thanks for making me feel a million times better about my face, it’s HUGE for me and I’m just so very grateful!” –Melissa A.
See why UluRx clients are loving their treatments
Why This Trio Out-Performs OTC
Pharmacist explains how to spot real copper peptides.
Pharmacist Explains the Difference Between Tretinoin and Retinol.
Deeper cellular turnover — clears texture, clogged pores, and dullness faster.
Prescription customization — tailored irritation profile, strength, and base.
Frequently Asked Questions
Have questions? We’ve got answers. Here’s a collection of the most common questions we hear. If you don’t find what you’re looking for, feel free to reach out.
Rebuilding collagen after menopause requires addressing hormonal signaling in the skin, stimulating cellular turnover, activating repair pathways, and providing the body with the nutrients required to support that repair. Estrogen decline directly affects collagen density, skin thickness, and elasticity. A comprehensive approach that combines topical hormonal support, cellular renewal, bioactive repair signals, and internal nutrition covers more of what changes in menopausal skin than any single product alone.
Estrogen plays a critical role in maintaining collagen production, skin thickness, hydration, and elasticity. As estrogen levels decline, collagen production slows, the skin becomes thinner, and structural support weakens. This is why many people notice rapid changes in skin firmness and texture during and after menopause.
Many routines focus only on moisturizers, acids, or antioxidants without addressing the underlying hormonal and cellular changes that occur with age. Without stimulating cell turnover, supporting collagen signaling, and addressing estrogen-related decline, results are often limited.
Long-term skin improvement after menopause happens when four areas are treated together:
Hormonal support in the skin to counter estrogen-related collagen loss
Cellular turnover stimulation to renew the skin and trigger repair
Bioactive peptide signaling to encourage collagen and elastin production
Internal nutritional support to provide the raw materials for rebuilding
This coordinated approach allows the skin to restore structure rather than temporarily improving appearance.
Estrogen helps regulate collagen production, skin thickness, hydration, and elasticity. Reduced estrogen levels are directly linked to accelerated collagen loss and skin thinning.
Increasing cellular turnover encourages the skin to shed damaged cells and initiate repair processes. This renewal process is closely tied to collagen remodeling and improved skin texture.
Copper peptides signal the skin to produce collagen, elastin, and other structural components involved in firmness and resilience.
Collagen production requires amino acids, vitamins, minerals, and antioxidants. Without these nutrients, the skin cannot effectively rebuild even when stimulated by topical treatments.
Improvements in texture and hydration may be noticed within weeks. Visible changes in firmness and elasticity typically appear after 8–12 weeks as collagen remodeling occurs.
It’s designed to. Supporting hormonal signaling, cell turnover and repair pathways can improve the look of fragile, thinning or crepey skin over time.
Moisturizers improve hydration but do not influence the biological processes responsible for collagen production or skin structure.
When used as part of a guided routine, these categories of ingredients are commonly used in dermatologic practice for ongoing skin maintenance and repair.
It’s designed to. Supporting collagen and cell renewal can help skin tone, brightness and resilience improve with consistent use.
While estrogen-related decline primarily affects women after menopause, the repair and collagen pathways supported by this approach benefit all aging skin.
Each component addresses a different biological pathway involved in collagen loss. When used together, they create a coordinated environment for the skin to rebuild structure.
The goal is to restore skin thickness, firmness, elasticity, and resilience by supporting the biological processes responsible for collagen production and repair.
Checkout
Add your item to cart and complete checkout as usual.
Prescription Check and Doctor Review
Complete a quick medical questionnaire after checkout.
Our licensed doctors review your answers and issue your prescription within 1–3 business days.
Formulation and Quality Check
Your custom formula is compounded and undergoes final safety and potency testing, which takes 2-4 business days.
Shipped to Your Door
Your personalized order is carefully packed and shipped with tracking details emailed immediately.