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🔒 LegitScript Certified  ·  Rx Included  ·  Licensed U.S. Pharmacy
AMPLIFY TIER

Smooth the Lines. Rebuild the Collagen.

For visible smoothing, firming, and full-face renewal

Three pharmacy-grade creams targeting collagen, elasticity, and texture — paired with daily inside-out support — for visible firming and smoothing across face, neck, and chest.

★★★★★

"My kids asked if I'd had a facelift thanks to UluRx." — Sara, Verified UluRx Client

First visible results in 2 to 12 weeks. Backed by our 30-day reformulation guarantee.

$449.99
Three creams + supplement.
One transformation.
What's in it: GHK-Cu Copper Peptides + Estriol Face Cream + Tretinoin Collagen Constructor + Ulu Ultimate Daily Supplement.
What you personalize: Strengths and ingredients in each cream, picked for YOU based on a free 1-min on-site skin quiz — preview your formula before you buy. 👉 Take the 1-Min Skin Quiz See exactly which ingredients go in YOUR custom bundle
🔒 LegitScript Certified  ·  Rx Included  ·  Licensed Pharmacy

Smooth the Lines. Rebuild the Collagen.

AMPLIFY TIER  ·  For visible smoothing, firming, and full-face renewal

AMPLIFY TIER
★★★★★ Verified UluRx Clients
$449.99 Three creams + supplement.  ·  One transformation.

"My kids asked if I'd had a facelift thanks to UluRx." — Sara, Verified UluRx Client

First visible results in 2 to 12 weeks. Backed by our 30-day reformulation guarantee.
What's in it: GHK-Cu Copper Peptides + Estriol Face Cream + Tretinoin Collagen Constructor + Ulu Ultimate Daily Supplement.
What you personalize: Strengths and ingredients in each cream, picked for YOU based on a free 1-min on-site skin quiz — preview your formula before you buy.
👉 Take the 1-Min Skin Quiz See exactly which ingredients go in YOUR custom bundle

Collagen à Trois Transformation System

Your Complete Face Routine for Smoothing Lines, Rebuilding Collagen, and Defending Skin From Within

Three targeted creams for face, neck, and chest—plus daily internal support to keep collagen working for you, not against you.

“My kids asked if I’d had a facelift thanks to UluRx.” — Sara, Real UluRx Client

$449.99 — available on subscription

Licensed Pharmacy
Prescription Included
HSA/FSA Eligible

Doctor and Pharmacist Designed to promote:

Doctor- and pharmacist-designed to support:

  • Smoother Lines
  • Firmer Skin
  • Brighter Tone
  • Lifted Look

Real Results

Product Details

The Collagen à Trois Transformation System is a full‑face anti‑aging plan built around three pharmacy‑grade creams plus the Ulu Ultimate Daily Supplement for inside‑out support. The three prescription-strength creams target collagen renewal and production from three angles, while the supplement adds 40+ ingredients to support healthy skin function, defend against oxidative stress, and boost glow. Together, they create a powerful routine for women who are serious about turning visible aging around—not just slowing it down.

What's Inside

This system is ideal if you:

  • See moderate to advanced signs of aging: etched lines, laxity, or crepey patches

  • Want a prescription‑strength, dermatologist‑style routine without building it product by product

  • Are in perimenopause, menopause, or post‑menopause and noticing thinner, less resilient skin

  • Are ready to commit to a structured plan that treats texture, firmness, tone, and overall skin health at the same time

With consistent use, most people notice:

  • Weeks 2–4: Skin feels smoother and more refined; early glow and softness return as turnover and barrier repair improve.

  • Weeks 6–8: Fine lines start to soften, tone looks more even, and skin feels bouncier and less “tired.”

  • Weeks 12+ and beyond: Visible improvement in firmness, deeper wrinkles, and crepey areas, with a healthier, more lifted look overall.

You will receive clear instructions from your provider on how to introduce tretinoin gradually, layer Estriol and Copper Peptides, and take Ultimate Daily every day with food. Consistency and steady use—not overdoing it—are what deliver the best long-term results.

“I’ve been using the GHK-Cu cream in my face for about two weeks and I already see a difference especially on my neck. Am I crazy or does this actually work that fast? … This product is unreal and more women my age should use it!”

“I’m 67 and have been using UluRx Copper Peptides for just 5 weeks. My skin looks amazing, and everyone is asking about my secret. The product is easy to use, and I’ve noticed a significant improvement in my skin’s texture and tone. I feel more youthful and confident. Highly recommend for anyone seeking noticeable results and a confidence boost! Thank you, UluRx, for such incredible skincare products! I’m eternally grateful.” –Sara

“I am on month 2 and let me tell you my skin has never looked this good before! The lines around my mouth and crows feet are disappearing. My skin feels so soft and radiant.” –Diane W., copper peptides client

“I am beyond GRATEFUL for this company and their products. I have been taking the supplements and using the acne Tretinoin script for about a year now, and it has made a world of difference in my skin. I started to get cystic acne after my second child around age 32, and I have been struggling fur the past 7 years. I’ve tried many products and nothing has worked. For me, less is more. My skin’s microbiome needs some help, but too many products only aggravates my skin. I have had my RX adjusted twice now to accommodate changes in my skin needs, and the great thing about this product is that pharmacists customize it for me :-) thanks for making me feel a million times better about my face, it’s HUGE for me and I’m just so very grateful!”  –Melissa A.

See why UluRx clients are loving their treatments

Why This Trio Out-Performs OTC

Pharmacist explains how to spot real copper peptides.

Pharmacist Explains the Difference Between Tretinoin and Retinol.

  • Deeper cellular turnover — clears texture, clogged pores, and dullness faster.

  • Prescription customization — tailored irritation profile, strength, and base.

Frequently Asked Questions

Have questions? We’ve got answers. Here’s a collection of the most common questions we hear. If you don’t find what you’re looking for, feel free to reach out.

Rebuilding collagen after menopause requires addressing hormonal signaling in the skin, stimulating cellular turnover, activating repair pathways, and providing the body with the nutrients required to support that repair. Estrogen decline directly affects collagen density, skin thickness, and elasticity. A comprehensive approach that combines topical hormonal support, cellular renewal, bioactive repair signals, and internal nutrition covers more of what changes in menopausal skin than any single product alone.

Estrogen plays a critical role in maintaining collagen production, skin thickness, hydration, and elasticity. As estrogen levels decline, collagen production slows, the skin becomes thinner, and structural support weakens. This is why many people notice rapid changes in skin firmness and texture during and after menopause.

Many routines focus only on moisturizers, acids, or antioxidants without addressing the underlying hormonal and cellular changes that occur with age. Without stimulating cell turnover, supporting collagen signaling, and addressing estrogen-related decline, results are often limited.

Long-term skin improvement after menopause happens when four areas are treated together:

  • Hormonal support in the skin to counter estrogen-related collagen loss

  • Cellular turnover stimulation to renew the skin and trigger repair

  • Bioactive peptide signaling to encourage collagen and elastin production

  • Internal nutritional support to provide the raw materials for rebuilding

This coordinated approach allows the skin to restore structure rather than temporarily improving appearance.

Estrogen helps regulate collagen production, skin thickness, hydration, and elasticity. Reduced estrogen levels are directly linked to accelerated collagen loss and skin thinning.

Increasing cellular turnover encourages the skin to shed damaged cells and initiate repair processes. This renewal process is closely tied to collagen remodeling and improved skin texture.

Copper peptides signal the skin to produce collagen, elastin, and other structural components involved in firmness and resilience.

Collagen production requires amino acids, vitamins, minerals, and antioxidants. Without these nutrients, the skin cannot effectively rebuild even when stimulated by topical treatments.

Improvements in texture and hydration may be noticed within weeks. Visible changes in firmness and elasticity typically appear after 8–12 weeks as collagen remodeling occurs.

It’s designed to. Supporting hormonal signaling, cell turnover and repair pathways can improve the look of fragile, thinning or crepey skin over time.

Moisturizers improve hydration but do not influence the biological processes responsible for collagen production or skin structure.

When used as part of a guided routine, these categories of ingredients are commonly used in dermatologic practice for ongoing skin maintenance and repair.

It’s designed to. Supporting collagen and cell renewal can help skin tone, brightness and resilience improve with consistent use.

While estrogen-related decline primarily affects women after menopause, the repair and collagen pathways supported by this approach benefit all aging skin.

Each component addresses a different biological pathway involved in collagen loss. When used together, they create a coordinated environment for the skin to rebuild structure.

The goal is to restore skin thickness, firmness, elasticity, and resilience by supporting the biological processes responsible for collagen production and repair.

Checkout

Add your item to cart and complete checkout as usual.

Prescription Check and Doctor Review

Complete a quick medical questionnaire after checkout.
Our licensed doctors review your answers and issue your prescription within 1–3 business days.

Formulation and Quality Check

Your custom formula is compounded and undergoes final safety and potency testing, which takes 2-4 business days.

Shipped to Your Door

Your personalized order is carefully packed and shipped with tracking details emailed immediately.