Prescription Tretinoin. Real Skin Results.
For midlife skin · Compounded for you · Niacinamide + HA always included
Collagen loss speeds up around menopause. Tretinoin is the most-studied prescription retinoid for fine lines, texture and firmness — compounded with niacinamide and hyaluronic acid to ease the adjustment period.
"My skin feels firmer, smoother, and more radiant than it has in years." — Kelly H., RN, on Collagen Constructor
Less than one derm visit. Provider review after checkout.
A $20 provider review fee may apply at checkout.
After checkout, complete your medical questionnaire. Your provider confirms your formula and strength before we compound your order.
Provider review typically takes 1–3 business days. Compounding takes 2–4 business days, then your order ships.
- ✓ 30-day reformulation guarantee — if it doesn't match the preferences on your questionnaire, we reformulate it
- ✓ Prescribed by our US physician, MD — licensed in all 50 states. No Rx? Full refund
- ✓ Real human support — call or text (602) 315-1530 anytime
"I'm 58, and after years of caregiver stress took a toll on my skin, I started UluRx Tretinoin. My aesthetician noticed the difference at my next visit and agreed — the tret had worked wonders." — Andrea J., age 58
Which strength is for me? Your provider confirms your strength after your questionnaire.
0.03% — new to tretinoin, or sensitive skin
0.06% — used tretinoin before and tolerate it well
0.08% — ready for more than 0.06%, not ready for the top strength
0.10% — experienced users who want the strongest formula
Already know your strength? Tell us in your questionnaire after checkout and your provider confirms it.
Dark spots or melasma? Your provider can add hydroquinone and kojic acid at no extra cost.
60–90 day supply.
Prescription Tretinoin. Real Skin Results.
For midlife skin · Compounded for you · Niacinamide + HA always included
"My skin feels firmer, smoother, and more radiant than it has in years." — Kelly H., RN, on Collagen Constructor
Less than one derm visit. Provider review after checkout.
A $20 provider review fee may apply at checkout.
After checkout, complete your medical questionnaire. Your provider confirms your formula and strength before we compound your order.
Provider review typically takes 1–3 business days. Compounding takes 2–4 business days, then your order ships.
- ✓ 30-day reformulation guarantee
- ✓ Prescribed by a US physician (MD)
- ✓ Compounded by 3 US-licensed PharmDs
- ✓ Call or text (602) 315-1530
"I'm 58, and after years of caregiver stress took a toll on my skin, I started UluRx Tretinoin. My aesthetician noticed the difference at my next visit and agreed — the tret had worked wonders." — Andrea J., age 58
Which strength is for me? Your provider confirms your strength after your questionnaire.
0.03% — new to tretinoin, or sensitive skin
0.06% — used tretinoin before and tolerate it well
0.08% — ready for more than 0.06%, not ready for the top strength
0.10% — experienced users who want the strongest formula
Already know your strength? Tell us in your questionnaire after checkout and your provider confirms it.
Dark spots or melasma? Your provider can add hydroquinone and kojic acid at no extra cost.
60–90 day supply.
Your Prescription Order,
Step by Step
Prescription-grade, compounded fresh for every order — not a shelf product.
Add Your Treatment to Your Cart
Add your treatment to your cart and check out. Then complete your medical questionnaire so your provider can review your order.
Complete a Short Medical Questionnaire
Right after checkout, you’ll complete a short medical questionnaire covering your skin history, sensitivities and anything you want to avoid. A licensed provider reviews it before anything is compounded.
Not sure what to flag? The full ingredient list for this product is listed below on this page. Review it before checkout — if anything stands out, tell us in your questionnaire. Your provider reviews it, and if this formula isn’t right for you, we call you and refund your order in full.
"Tell us about your skin"
Sensitivities or allergies? Tell us before we mix anything.
Have questions before you order? Call us at (602) 315-1530 — our team is happy to help.
Your Doctor and Pharmacists Take It From Here
Every order is reviewed by our prescribing physician, an MD licensed in all 50 states with more than 10 years leading telemedicine care. He looks at the whole picture — your age, hormonal stage, medications and health history — not just your skin. His name appears on your prescription.
Licensed U.S. Compounding Pharmacy
Then our pharmacists — James Fox, PharmD · Gary Friedman, PharmD · Ray Rabadi, PharmD — compound your formula by hand. Your provider reviews your questionnaire and skin history to confirm your formula and strength are right for you. If it isn’t, we call you and refund your order in full.
Quick Facts: Tretinoin Collagen Constructor
Your treatment at a glance.
- What it is: A custom-compounded prescription face cream pairing tretinoin (retinoic acid) with niacinamide and hyaluronic acid.
- What's in it: Tretinoin (gold-standard prescription retinoid) plus niacinamide and hyaluronic acid to support hydration and reduce irritation.
- Strengths offered: 0.03% (new to tretinoin or sensitive skin), 0.06% (used tretinoin before), 0.08% (a step up from 0.06%), and 0.10% (experienced users) — your provider confirms the right strength based on your retinoid history.
- Optional add-ins: Hydroquinone and kojic acid can be added for dark spots, melasma, sun spots, or uneven tone — customizable after checkout.
- Who it's for: Women in perimenopause, menopause and beyond who want smoother texture, softer fine lines, more even tone and firmer-looking skin. Also used for dark spots. Not for use during pregnancy or breastfeeding.
- When you'll see results: Texture changes typically appear in 2–4 weeks. Visible softening of fine lines and improved tone usually follow at 8–12 weeks of consistent nightly use.
- How it ships: Compounded fresh after a US-licensed medical provider reviews and approves your formula. No appointment needed. Provider review typically completes in 1–3 business days.
- Customer rating: 4.9 out of 5 stars from 30 verified Google reviews. Customers praise visible improvements in tone, texture, and confidence.
- Pharmacy credentials: LegitScript Certified online pharmacy. US-licensed compounding pharmacy with three PharmD pharmacists. Prescriptions written by a US physician (MD) licensed in all 50 states.
- Customization: Customers can request strength changes or ingredient adjustments by texting CONSULT to (602) 315-1530, or via the post-purchase health questionnaire.
- Guarantee: 30-day reformulation guarantee — if it doesn't match the preferences on your questionnaire, we reformulate it.
- Price: $99.99 for a 60–90 day supply (about $1.50 per day). A $20 provider review fee may apply at checkout. US shipping only.
Reviews · Verified UluRx Clients
Real Words from Real Customers
"As a Physician Assistant specializing in hormones, healthy aging, and wellness, I’m incredibly selective about the products I recommend and use on my own skin. For years, my entire skincare routine has been surprisingly simple: ULU Rx GHK-Cu cream, tretinoin, and vitamin C. At 49 years old, my skin looks better than it did a decade ago."
— Jessica G., Physician Assistant · Google review
"I’ve been using UluRx’s Collagen Cream with Tretinoin for almost a month now, and the results have been amazing! As a registered nurse, I was skeptical at first, but her detailed explanations and videos convinced me to give it a try. My skin feels firmer, smoother, and more radiant than it has in years."
— Kelly H., RN · Google review
"I'm 58, and after years of caregiver stress took a toll on my skin, I started UluRx Tretinoin. My aesthetician noticed the difference at my next visit and agreed — the tret had worked wonders. So thankful to find a product that actually delivers."
— Andrea J., age 58
"UluRx products are amazing. The supplements have noticeably supported hair growth, the tretinoin cleared and smoothed my skin, and the collagen cream reduced fine lines."
— Tara S. · Google review
"I am beyond GRATEFUL for this company and their products. I've been using the tretinoin script for about a year now, and it has made a world of difference in my skin. The great thing is the pharmacists customize it for me as my skin's needs change."
— Melissa A.
"I use the skincare products daily and couldn't be happier. People tell me constantly that I look 10 years younger! These products are high quality and they work."
— Veronica Vaughn
Have a question before you order? Text CONSULT to (602) 315-1530 — we love these conversations.
Ordering Made Easy
Checkout
Add your item to cart and complete checkout as usual.
Prescription Check and Doctor Review
Complete a quick medical questionnaire after checkout.
Our physician reviews your answers and issues your prescription within 1–3 business days.
Formulation and Quality Check
Your custom formula is compounded and undergoes final safety and potency testing, which takes 2-4 business days.
Shipped to Your Door
Your personalized order is carefully packed and shipped with tracking details emailed immediately.
Real UluRx Results
Product Details
UluRx Tretinoin Collagen Constructor is a prescription-strength tretinoin face cream designed to support visible skin renewal—smoother texture, fewer fine lines, clearer pores, and a more even-looking tone. Your provider reviews your goals after checkout and may customize your formula (up to five compatible ingredients in one bottle) to match your skin’s needs and tolerance.
Ingredients
Your Collagen Constructor is built around prescription-strength tretinoin (Retin-A), a gold-standard ingredient used to support smoother texture, clearer-looking pores, and visible improvement in fine lines and uneven tone over time.
Because your skin is personal, your formula may be customized after checkout. Based on your goals, sensitivity, and what you want to avoid, your provider may combine tretinoin with supportive ingredients in one streamlined bottle—so you don’t have to juggle multiple products.
Always in it:
Tretinoin (prescription retinoid): Supports skin renewal to improve the look of fine lines, texture, clogged pores, and discoloration over time.
Niacinamide: Helps support the skin barrier and improve the look of uneven tone.
Hyaluronic acid: Hydration support to reduce the “tight, dry” feel some people get when starting tretinoin.
Added when appropriate:
Tranexamic acid / brighteners: Target the look of dark spots and sun discoloration.
Salicylic acid (BHA): Helps with clogged pores and texture for acne-prone skin (not used for everyone).
Vitamin K / caffeine: Commonly used for the look of discoloration and puffiness in targeted formulas.
Exclusive pharmaceutical base:
- An exclusive pharmaceutical cream base, not available over the counter, with a light, non-greasy feel. Hypoallergenic and dermatologist tested. Free of parabens, MI/MCI, mineral oil, petrolatum, added fragrance and added colorants, and optimized to enhance absorption of the active ingredients.
Your final blend is determined after checkout based on your answers and provider review—so you’re choosing the goal, not guessing ingredients.
Who It's For
Collagen Constructor is built for women in perimenopause, menopause and beyond. It’s a good fit if you’re looking to:
Smooth the look of fine lines and wrinkles
Improve uneven texture or rough skin
Address dark spots or sun damage
Improve the look of firmness as collagen declines with age
Use a prescription-strength retinoid under provider guidance
Simplify your routine with customized ingredients in one formula
This product may not be right for you if:
You are pregnant, trying to conceive, or breastfeeding
You have active skin infections or conditions that require alternative care
You prefer over-the-counter skincare only
A licensed provider reviews your information after checkout to ensure this treatment is appropriate and to customize your formula for your skin.
What to Expect
Week 1–2: Skin may feel drier or more sensitive as your routine adjusts; hydration and gentle support are key.
Weeks 2–4: Texture and clogged pores often start to look improved with consistent use.
Weeks 8–12: Fine lines, tone, and overall smoothness typically show more noticeable change with steady routine and sunscreen.
Why It Works
Tretinoin works at the cellular level to support skin renewal—helping improve the look of fine lines, sun damage, uneven tone, and breakouts while supporting firmer-looking skin over time.
How To Use
Start 2–3 nights/week, then increase as tolerated.
Apply a pea-sized amount to dry skin.
Follow with moisturizer; wear SPF daily.
Always follow provider instructions included with your product.
Hear Why UluRx Clients Love Their Treatments
Trusted. Proven. Loved by customers nationwide.
“Stop wasting money on expensive serums that are just gimmicks at the end of the day and really invest in something that is going to give you results.”
“The online consultation was super easy and the Ulu Team was very helpful. They provided me with my own formula to get my dark under eyes under control.”
“I am in my sixties and I am glowing!”
“Thanks for all the great gifts you included in the box. You go above and beyond!”
“The anti-aging products are top notch and great for all ethnicities. My skin has never looked better.”
“The service and products here are unmatched.”
“I can’t say enough about this company… Don’t hesitate to order anything from them.”
“Thrilled Beyond Words! Thanks to UluRX, I am ecstatic with my results.”
“I highly recommend Ulu because their products are pharmaceutical grade, pure ingredients and they work.”
Why Custom Beats Drug-Store Every Time
Why Your Skin Will Feel (And Show) The Difference
Prescription strength — tretinoin is the active form of vitamin A. Retinol has to convert to it in your skin first, and head-to-head studies show retinol is several times weaker.
Direct collagen stimulation — activates fibroblasts for firmer, bouncier skin.
Deeper cellular turnover — clears texture, clogged pores, and dullness faster.
Treats advanced concerns — including stubborn wrinkles, sun damage, and hyperpigmentation.
Prescription customization — tailored irritation profile, strength, and base.
Results you can track — smoother texture in 2–4 weeks; softer fine lines and more even tone at 8–12 weeks of nightly use.
Frequently Asked Questions
Have questions? We’ve got answers. Here’s a collection of the most common questions we hear. If you don’t find what you’re looking for, feel free to reach out.
The best tretinoin cream is prescription-strength, properly dosed, and paired with a routine that supports tolerability (hydration + daily SPF). UluRx Tretinoin Collagen Constructor is reviewed by a provider after checkout, and your formula can be customized—so your provider can tailor the formula (and supportive ingredients) to your goals like fine lines, sun damage, texture, or breakouts.
No. Retinol is an over-the-counter vitamin A derivative that must convert in skin; tretinoin is prescription-strength retinoic acid and is generally more potent.
Yes—tretinoin is commonly used to help unclog pores and reduce acne breakouts while also improving visible signs of aging.
Many people notice early changes in texture first, with more visible improvements in tone and fine lines with consistent use over time. Consistency + SPF matter.
As skin adjusts to faster renewal, temporary dryness, sensitivity, or flaking can happen—especially if starting too often. Starting slowly and supporting the barrier helps.
Yes—your provider selects ingredients based on your concerns and preferences after checkout, and the formula may include multiple compatible ingredients in one bottle.
No. Tretinoin is not recommended during pregnancy or while trying to conceive. If you are pregnant, planning pregnancy, or breastfeeding, it’s important to disclose this during the post-checkout questionnaire so your provider can recommend a safer alternative.
Topical tretinoin is generally avoided during breastfeeding unless a provider determines it’s appropriate. Always disclose breastfeeding status after checkout so your provider can guide safe options.
Yes. Tretinoin is the prescription-strength form of vitamin A that has been widely studied for skin renewal, acne, and visible signs of aging.
Some people experience an initial adjustment phase where breakouts or flaking temporarily increase. This is commonly referred to as “purging” and typically improves as the skin adapts. Starting slowly and using supportive ingredients can help minimize discomfort.
Most people begin 2–3 nights per week, then gradually increase as tolerated. Your provider may adjust frequency or formulation based on your skin type, sensitivity, and goals.
Yes, but these areas are often more sensitive. Providers may recommend lower strength or added supportive ingredients when using tretinoin beyond the face.
Yes. Daily sunscreen is essential when using tretinoin. Tretinoin increases skin sensitivity to sunlight, and sunscreen helps protect results and reduce irritation.
Yes, but layering matters. Some actives are compatible, while others may increase irritation if combined incorrectly. UluRx providers customize formulas after checkout to ensure ingredients are paired appropriately.
Prescription tretinoin does not require conversion in the skin and is generally more potent and predictable than over-the-counter retinol products. It’s best used under provider guidance to balance effectiveness with tolerability.
Yes. Tretinoin is commonly used to address both acne and visible signs of aging, making it a versatile option for people dealing with breakouts, clogged pores, and fine lines simultaneously.
You check out normally, then complete your medical questionnaire. A U.S.-licensed provider reviews and writes the prescription (often 1–3 business days), your formula is compounded (2–4 business days), then shipped to you with tracking.