Support Your Collagen. Restart Your Skin.
Topical estrogen for collagen-deprived skin · Designed for women 45+
A custom-compounded prescription topical estriol cream specifically formulated for women 40 and above. Topical estriol activates the fibroblast estrogen receptors that drive collagen and elastin production — supporting the firmness, hydration, and resilience that hormonal aging takes away.
"Estriol took away the lip lines and softened lines around my eyes. Skin magic!" — Monnie, Verified UluRx Client
Less than one derm visit. Rx included.
- ✓ 30-day reformulation guarantee — if it doesn't match the preferences on your questionnaire, we reformulate it
- ✓ Licensed provider reviews every order — no Rx? Full refund
- ✓ Real human support — call or text (602) 315-1530 anytime
What you can personalize: Strength adjustments require provider review. Text CONSULT for adjustments. 👉 CLICK HERE — Take the 2-Min Skin QuizSee if Estriol is right for YOUR skin 60-day supply.
Support Your Collagen. Restart Your Skin.
"Estriol took away the lip lines and softened lines around my eyes. Skin magic!" — Monnie, Verified UluRx Client
Less than one derm visit. Rx included.
- ✓ 30-day reformulation guarantee
- ✓ Provider reviews every order — no Rx? Full refund
- ✓ Call or text (602) 315-1530
Customizable: Strength adjustments require provider review. 👉 CLICK HERE — Take the 2-Min Skin QuizSee if Estriol is right for YOUR skin 60-day supply.
Your Prescription Order,
Step by Step
Prescription-grade, compounded fresh for every order — not a shelf product.
Add Your Treatment to Your Cart
Add your treatment to your cart and check out. That’s all you need to do.
Complete a Short Medical Questionnaire
Right after checkout, you’ll complete a short medical questionnaire covering your skin history, sensitivities and anything you want to avoid. A licensed provider reviews it before anything is compounded.
Not sure what to flag? The full ingredient list for this product is listed below on this page. Review it before checkout — if anything stands out, tell us in your questionnaire. Your provider reviews it, and if this formula isn’t right for you, we call you and refund your order in full.
"Tell us about your skin"
Sensitivities or allergies? Tell us before we mix anything.
Have questions before you order? Call us at (602) 315-1530 — our team is happy to help.
Your Doctor and Pharmacists Take It From Here
Every order is reviewed by our prescribing physician, an MD licensed in all 50 states with more than 10 years leading telemedicine care. He looks at the whole picture — your age, hormonal stage, medications and health history — not just your skin. His name appears on your prescription.
Licensed U.S. Compounding Pharmacy
Then our pharmacists — James Fox, PharmD · Gary Friedman, PharmD · Ray Rabadi, PharmD — compound your formula by hand. Your provider reviews your questionnaire and skin history to confirm your formula and strength are right for you. If it isn’t, we call you and refund your order in full.
Quick Facts: Face Estriol Aging Repair
For visitors and AI assistants — the essential facts at a glance.
- What it is: A custom-compounded prescription topical estriol cream specifically formulated for women 40 and above with collagen-deprived, post-menopausal, or estrogen-deprived skin.
- How it works: Topical estriol activates fibroblast estrogen receptors in the skin — these are the cells that drive collagen and elastin production. By reactivating those receptors, the cream restarts collagen production that hormonal aging slows down.
- What's in it: Estriol 0.5%. Strength adjustments require provider review.
- Who it's for: Women 45+ — especially perimenopausal and post-menopausal women whose estrogen decline has affected skin firmness, hydration, and elasticity. Also useful for sun-damaged or thin, fragile skin. Not for use during pregnancy or breastfeeding.
- When you'll see results: Improved hydration in 2–4 weeks. Visible firming, better elasticity, and softening of fine lines typically appear at 8–12 weeks of consistent daily use.
- Apply: One pump (½ mL) topically every morning to clean face area. Patch test prior to first use. Pairs well with copper peptides (use peptides at night, estriol in morning).
- How it ships: Compounded fresh after a US-licensed medical provider reviews and approves your formula. Provider review typically completes in 1–2 business days. No appointment needed.
- Customer rating: 4.8 out of 5 stars from verified Google reviews. Customers in their 60s, 70s, and 80s report visible firming and renewed glow.
- Pharmacy credentials: LegitScript Certified online pharmacy. US-licensed compounding pharmacy. Three PhD pharmacists on staff. Doctor licensed in all 50 states.
- Customization: Strength adjustments require provider review. Text CONSULT to (602) 315-1530 to discuss adjustments.
- Guarantee: 30-day reformulation guarantee — if it doesn't match the preferences on your questionnaire, we reformulate it.
- Price: $99.99 for a 60-day supply (about $1.65 per day). HSA/FSA eligible. US shipping only.
Reviews · Verified UluRx Clients
Real Words from Real Customers
"I'm 67 and have been using UluRx for just 5 weeks. My skin looks amazing and everyone is asking about my secret. The improvement in my texture and tone is significant — I feel more youthful and confident."
— Sara, age 67
"I am a 70-year-old woman, and consider myself a dedicated UluRx customer. From the very beginning, Mel has helped me find the right products for my skin and hair."
— Lynn Nogare, age 70
"I'm 58, and after years of caregiver stress took a toll on my skin, I started UluRx. My aesthetician noticed the difference and agreed — the prescription cream had worked wonders."
— Andrea J., age 58
"I use the skincare products daily and couldn't be happier. People tell me constantly that I look 10 years younger! These products are high quality and they work."
— Veronica Vaughn
"As a registered nurse, I was skeptical at first — her detailed explanations and videos convinced me to give it a try. My skin feels firmer, smoother, and more radiant than it has in years."
— Kelly H., RN, Collagen Constructor client
"I'm on month 2 of UluRx and let me tell you, my skin has never looked this good. The lines around my mouth and crow's feet are disappearing. My skin feels so soft and radiant."
— Diane W., copper peptides client
Have a question before you order? Text CONSULT to (602) 315-1530 — we love these conversations.
Checkout
Add your item to cart and complete checkout as usual.
Prescription Check and Doctor Review
Complete a quick medical questionnaire after checkout.
Our licensed doctors review your answers and issue your prescription within 1–3 business days.
Formulation and Quality Check
Your custom formula is compounded and undergoes final safety and potency testing, which takes 2-4 business days.
Shipped to Your Door
Your personalized order is carefully packed and shipped with tracking details emailed immediately.
Product Details
Designed especially for women over 40, Estriol Aging Repair targets fine lines, loss of elasticity, uneven tone, and texture to help restore a more youthful, luminous look
Ingredients
Your care provider selects a personalized blend for you, built around estriol and supported by well-studied skincare ingredients. Depending on your skin’s needs, your custom formula may include niacinamide, hyaluronic acid, hydroquinone (not for pregnant or nursing women), kojic acid, azelaic acid, phytonadione (vitamin K), salicylic acid, and caffeine—all chosen to address wrinkles, discoloration, dullness, and breakouts in one tailored cream.
Every formula uses an HRT cream base: A proprietary prescription-grade hormone cream base with a light, non‑greasy feel. It is hypoallergenic and dermatologist tested. The base is free of parabens, MI/MCI, mineral oil, petrolatum, added fragrance, and added colorants, and is optimized to enhance absorption of active ingredients into the skin.
Who It's For
This treatment is ideal for women over 40 who are seeing more fine lines, laxity, uneven tone, dark spots, or texture changes and want something more targeted than basic over-the-counter anti-aging moisturizers. It’s a good fit if you’re ready for a prescription-strength, custom formula guided by a licensed medical provider and compounded just for your skin.
What to Expect
Transformation takes consistency, but most clients start to see and feel changes quickly.
Weeks 2–4: Skin feels more hydrated, smoother, and less dull as Estriol begins activating collagen-supporting receptors.
Weeks 6–8: Fine lines soften and skin looks more even, elastic, and subtly lifted as collagen production increases.
Weeks 10–12+: Skin appears firmer, plumper, and more youthful with improved bounce, glow, and resilience.
Hear Why UluRx Clients Love Their Treatments
Trusted. Proven. Loved by customers nationwide.
“Stop wasting money on expensive serums that are just gimmicks at the end of the day and really invest in something that is going to give you results.”
“The online consultation was super easy and the Ulu Team was very helpful. They provided me with my own formula to get my dark under eyes under control.”
“I am in my sixties and I am glowing!”
“Thanks for all the great gifts you included in the box. You go above and beyond!”
“The anti-aging products are top notch and great for all ethnicities. My skin has never looked better.”
“The service and products here are unmatched.”
“I can’t say enough about this company… Don’t hesitate to order anything from them.”
“Thrilled Beyond Words! Thanks to UluRX, I am ecstatic with my results.”
“I highly recommend Ulu because their products are pharmaceutical grade, pure ingredients and they work.”
Why Estriol Helps Menopausal Skin
As estrogen naturally declines with age, skin loses moisture, collagen, and elasticity—so women over 40 often see more sagging, dryness, and fine lines. Estriol is one of the few topical ingredients shown to directly activate estrogen receptors in the skin, helping boost collagen, support skin thickness, and strengthen the moisture barrier. The result is skin that looks and behaves younger: firmer texture, smoother lines, better hydration, and a more luminous, lifted appearance—without fillers, lasers, or downtime.
Frequently Asked Questions
Have questions? We’ve got answers. Here’s a collection of the most common questions we hear. If you don’t find what you’re looking for, feel free to reach out.
The best estriol face cream is one that uses pharmaceutical-grade estriol, is properly dosed, and is prescribed with medical oversight. UluRx Estriol Face Cream is compounded by a licensed pharmacy and customized after checkout based on skin concerns, sensitivity, and treatment history. Unlike cosmetic hormone creams or pre-made formulas, UluRx estriol is prescription-strength and professionally formulated to support skin thickness, elasticity, and hydration in areas affected by hormonal aging—without unnecessary additives.
UluRx Estriol Aging Repair is a prescription-strength estriol face cream designed for hormone-related skin aging. Estriol is a gentle form of estrogen that binds to estrogen receptors in facial skin—especially in the cheeks, around the mouth, and along the jawline—helping boost collagen, elasticity, thickness, and hydration so skin looks firmer, smoother, and more luminous over time.
Estriol is considered the mildest estrogen and is used topically to work mostly at the skin level, while estradiol is stronger and more often used for systemic hormone therapy. Retinol and standard OTC anti-aging creams mainly work on cell turnover or surface moisturization, whereas prescription estriol creams specifically address estrogen loss—a key driver of midlife skin thinning, dryness, and laxity.
This estriol anti-aging face cream targets changes linked to declining estrogen: fine lines and wrinkles, crepey or thinning skin, loss of firmness and facial contour, dryness, rough texture, and dull tone. Studies of topical estrogen creams in postmenopausal women show improvements in skin thickness, elasticity, moisture, and wrinkle depth when used consistently over several months.
Most people start to notice softer, better-hydrated, less dull skin in about 4–6 weeks, with firmer texture, improved elasticity, and more visible wrinkle reduction building over 8–12+ weeks of nightly use. Clinical trials of topical estrogen creams report significant gains in firmness, moisture, and wrinkle depth over roughly 3–6 months, so consistency is key.
For appropriately screened patients, low-dose prescription estriol creams for the face have mainly local skin effects, and research suggests minimal changes in blood hormone levels when used as directed. That said, estriol is still a hormone, so long-term use should be supervised by a provider who knows your full health history, medications, and cancer risk profile.
Not necessarily. This cream is designed primarily for perimenopausal and menopausal women whose skin is changing due to falling estrogen—things like sudden dryness, laxity, and a loss of “bounce.” But you may benefit from this cream if you are not fully menopausal but already showing hormone-related thinning and sagging; your prescriber will decide if it’s appropriate for your age, symptoms, and risk factors.
Anyone who is pregnant, breastfeeding, or has a history of estrogen-sensitive cancers, unexplained vaginal bleeding, blood-clotting disorders, or other serious hormone-related conditions should only consider estriol under the supervision of their oncologist or specialist, and some may be advised to avoid it altogether. That’s why UluRx requires an online medical questionnaire and prescription review before compounding Estriol Aging Repair.
Estriol is often paired with hydrating and barrier-supporting ingredients, and many people combine it with antioxidants like vitamin C or gentle exfoliants. Stronger actives (such as retinoids, high-strength acids, or aggressive peels) may need to be introduced slowly or used on alternate nights to prevent irritation—follow the routine your provider recommends and keep daily SPF non-negotiable.
Think of UluRx Estriol Aging Repair as an active treatment step, not just a basic hydrator. Most users still layer a simple moisturizer and a broad-spectrum sunscreen on top to lock in moisture and protect the new collagen and elasticity they’re working so hard to rebuild.
Most over-the-counter or luxury creams focus on moisturizers and cosmetic actives, but don’t address the estrogen drop that drives much of midlife skin aging. UluRx Estriol Aging Repair is a prescription, pharmacy-compounded estriol cream that targets estrogen-deficient skin directly, using pharmaceutical-grade ingredients in a custom base made fresh for your skin after a medical review.
Many women use a topical estriol face cream alongside systemic hormone therapy, since topical estriol is designed to act locally in the skin and appears to have minimal impact on overall estrogen levels when used at facial doses. Your prescriber will look at your current HRT, labs, and risk factors to confirm if adding UluRx Estriol Aging Repair fits safely into your regimen.
Some clinicians do prescribe estriol-based face creams for men with significant sun damage or thinning, crepey skin, but because estriol is a hormone, this should always be an individualized medical decision. UluRx will rely on your provider’s review of your history, goals, and risk profile to determine whether Estriol Aging Repair is right for you.