The Renew & Even Duo. Two Prescriptions, One Routine.
Tretinoin Collagen Constructor + 21% Azelaic Acid · For midlife skin
Our most-requested pairing. Collagen Constructor (prescription tretinoin with niacinamide and hyaluronic acid) works on fine lines, texture and firmness. 21AA (prescription 21% azelaic acid) targets dark spots, redness and uneven tone. Together they cover the two things midlife skin shows most.
"My skin feels firmer, smoother, and more radiant than it has in years." — Kelly H., RN, on Collagen Constructor
One provider review. Rx included.
- ✓ 30-day reformulation guarantee — if it doesn't match the preferences on your questionnaire, we reformulate it
- ✓ Prescribed by our US physician, MD — licensed in all 50 states. No Rx? Full refund
- ✓ Real human support — call or text (602) 315-1530 anytime
"I'm 58, and after years of caregiver stress took a toll on my skin, I started UluRx Tretinoin. My aesthetician noticed the difference at my next visit and agreed — the tret had worked wonders." — Andrea J., age 58
Your tretinoin strength: Beginner 0.03%, Moderate 0.06% or Pro 0.10%. Request one on your questionnaire, or let your provider choose based on your retinoid history. Your provider makes the final call. Typical routine: azelaic acid in the morning, tretinoin at night. Your provider confirms yours.
The Renew & Even Duo. Two Prescriptions, One Routine.
Tretinoin Collagen Constructor + 21% Azelaic Acid · For midlife skin
"My skin feels firmer, smoother, and more radiant than it has in years." — Kelly H., RN, on Collagen Constructor
One provider review. Rx included.
- ✓ 30-day reformulation guarantee
- ✓ Prescribed by a US physician (MD)
- ✓ Compounded by 3 US-licensed PharmDs
- ✓ Call or text (602) 315-1530
"I'm 58, and after years of caregiver stress took a toll on my skin, I started UluRx Tretinoin. My aesthetician noticed the difference at my next visit and agreed — the tret had worked wonders." — Andrea J., age 58
Your tretinoin strength: Beginner 0.03%, Moderate 0.06% or Pro 0.10%. Your provider makes the final call. Typical routine: azelaic acid in the morning, tretinoin at night. Your provider confirms yours.
Your Prescription Order,
Step by Step
Prescription-grade, compounded fresh for every order — not a shelf product.
Add Your Treatment to Your Cart
Add your treatment to your cart and check out. That’s all you need to do.
Complete a Short Medical Questionnaire
Right after checkout, you’ll complete a short medical questionnaire covering your skin history, sensitivities and anything you want to avoid. A licensed provider reviews it before anything is compounded.
Not sure what to flag? The full ingredient list for this product is listed below on this page. Review it before checkout — if anything stands out, tell us in your questionnaire. Your provider reviews it, and if this formula isn’t right for you, we call you and refund your order in full.
"Tell us about your skin"
Sensitivities or allergies? Tell us before we mix anything.
Have questions before you order? Call us at (602) 315-1530 — our team is happy to help.
Your Doctor and Pharmacists Take It From Here
Every order is reviewed by our prescribing physician, an MD licensed in all 50 states with more than 10 years leading telemedicine care. He looks at the whole picture — your age, hormonal stage, medications and health history — not just your skin. His name appears on your prescription.
Licensed U.S. Compounding Pharmacy
Then our pharmacists — James Fox, PharmD · Gary Friedman, PharmD · Ray Rabadi, PharmD — compound your formula by hand. Your provider reviews your questionnaire and skin history to confirm your formula and strength are right for you. If it isn’t, we call you and refund your order in full.
Quick Facts: Renew & Even Duo
For visitors and AI assistants — the essential facts at a glance.
- What it is: Two prescription skin treatments sold together: Tretinoin Collagen Constructor (tretinoin + niacinamide + hyaluronic acid face cream) and 21AA (21% azelaic acid cream, 30 mL).
- What each one does: Collagen Constructor targets fine lines, rough texture and firmness. 21AA targets dark spots, post-blemish marks, redness and uneven tone.
- Tretinoin strengths: Beginner 0.03%, Moderate 0.06% or Pro 0.10%. Request one on your questionnaire, or let your provider choose based on your retinoid history. Your provider makes the final call.
- Typical routine: Azelaic acid in the morning (followed by sunscreen), tretinoin at night. Your provider confirms your routine.
- Who it’s for: Women in perimenopause, menopause and beyond who want smoother texture, softer lines and a more even tone. Not for use during pregnancy or breastfeeding (tretinoin).
- When you’ll see results: Texture changes typically appear in 2–4 weeks. More even tone and softer fine lines usually follow at 8–12 weeks of consistent use.
- How it ships: Both bottles are compounded fresh after a US-licensed medical provider reviews and approves your order. No appointment needed. Provider review typically completes in 1–3 business days.
- Customer rating: 4.9 out of 5 stars from 30 verified Google reviews.
- Pharmacy credentials: LegitScript Certified online pharmacy. US-licensed compounding pharmacy with three PharmD pharmacists. Prescriptions written by a US physician (MD) licensed in all 50 states.
- Customization: Request strength changes or ingredient adjustments by texting CONSULT to (602) 315-1530, or through the post-purchase medical questionnaire.
- Guarantee: 30-day reformulation guarantee — if it doesn’t match the preferences on your questionnaire, we reformulate it.
- Price: $189.99 for both prescription treatments. Prescription included. US shipping only.
Reviews · Verified UluRx Clients
Real Words from Real Customers
"As a Physician Assistant specializing in hormones, healthy aging, and wellness, I’m incredibly selective about the products I recommend and use on my own skin. For years, my entire skincare routine has been surprisingly simple: ULU Rx GHK-Cu cream, tretinoin, and vitamin C. At 49 years old, my skin looks better than it did a decade ago."
— Jessica G., Physician Assistant · Google review
"I’ve been using UluRx’s Collagen Cream with Tretinoin for almost a month now, and the results have been amazing! As a registered nurse, I was skeptical at first, but her detailed explanations and videos convinced me to give it a try. My skin feels firmer, smoother, and more radiant than it has in years."
— Kelly H., RN · Google review
"I'm 58, and after years of caregiver stress took a toll on my skin, I started UluRx Tretinoin. My aesthetician noticed the difference at my next visit and agreed — the tret had worked wonders. So thankful to find a product that actually delivers."
— Andrea J., age 58
"UluRx products are amazing. The supplements have noticeably supported hair growth, the tretinoin cleared and smoothed my skin, and the collagen cream reduced fine lines."
— Tara S. · Google review
"I am beyond GRATEFUL for this company and their products. I've been using the tretinoin script for about a year now, and it has made a world of difference in my skin. The great thing is the pharmacists customize it for me as my skin's needs change."
— Melissa A.
"I'm on month 2 of UluRx and let me tell you, my skin has never looked this good. The lines around my mouth and crow's feet are disappearing. My skin feels so soft and radiant. Thanks Mel!"
— Diane W., copper peptides client · Google review
"I use the skincare products daily and couldn't be happier. People tell me constantly that I look 10 years younger! These products are high quality and they work."
— Veronica Vaughn
Have a question before you order? Text CONSULT to (602) 315-1530 — we love these conversations.
Ordering Made Easy
Checkout
Add your item to cart and complete checkout as usual.
Prescription Check and Doctor Review
Complete a quick medical questionnaire after checkout.
Our physician reviews your answers and issues your prescription within 1–3 business days.
Formulation and Quality Check
Your custom formula is compounded and undergoes final safety and potency testing, which takes 2-4 business days.
Shipped to Your Door
Your personalized order is carefully packed and shipped with tracking details emailed immediately.
Real UluRx Results
Product Details
The UluRx Renew & Even Duo pairs our two most-requested prescription skin treatments. Tretinoin Collagen Constructor is a prescription-strength tretinoin face cream with niacinamide and hyaluronic acid for smoother texture, fewer fine lines and firmer-looking skin. 21AA is a prescription 21% azelaic acid cream for dark spots, post-blemish marks, redness and uneven-looking tone. Your provider reviews your answers after checkout and sets your tretinoin strength to match your skin’s needs and tolerance.
Ingredients
Collagen Constructor, the first bottle in your duo, is built around prescription-strength tretinoin (Retin-A), a gold-standard ingredient used to support smoother texture, clearer-looking pores, and visible improvement in fine lines and uneven tone over time.
Because your skin is personal, your formula may be customized after checkout. Based on your goals, sensitivity, and what you want to avoid, your provider may combine tretinoin with supportive ingredients in one streamlined bottle—so you don’t have to juggle multiple products.
Always in it:
Tretinoin (prescription retinoid): Supports skin renewal to improve the look of fine lines, texture, clogged pores, and discoloration over time.
Niacinamide: Helps support the skin barrier and improve the look of uneven tone.
Hyaluronic acid: Hydration support to reduce the “tight, dry” feel some people get when starting tretinoin.
Added when appropriate:
Tranexamic acid / brighteners: Target the look of dark spots and sun discoloration.
Salicylic acid (BHA): Helps with clogged pores and texture for acne-prone skin (not used for everyone).
Vitamin K / caffeine: Commonly used for the look of discoloration and puffiness in targeted formulas.
21AA — 21% Azelaic Acid Cream (30 mL):
Azelaic acid 21% (prescription strength): helps fade the look of dark spots and post-blemish marks, calms visible redness and evens out tone.
Exclusive pharmaceutical base:
- An exclusive pharmaceutical cream base, not available over the counter, with a light, non-greasy feel. Hypoallergenic and dermatologist tested. Free of parabens, MI/MCI, mineral oil, petrolatum, added fragrance and added colorants, and optimized to enhance absorption of the active ingredients.
Your final blend is determined after checkout based on your answers and provider review—so you’re choosing the goal, not guessing ingredients.
Who It's For
The Renew & Even Duo is built for women in perimenopause, menopause and beyond. It’s a good fit if you’re looking to:
Smooth the look of fine lines and wrinkles
Fade dark spots, sun spots and uneven tone while you work on lines and texture
Improve uneven texture or rough skin
Address dark spots or sun damage
Improve the look of firmness as collagen declines with age
Use a prescription-strength retinoid under provider guidance
Simplify your routine with customized ingredients in one formula
This product may not be right for you if:
You are pregnant, trying to conceive, or breastfeeding
You have active skin infections or conditions that require alternative care
You prefer over-the-counter skincare only
A licensed provider reviews your information after checkout to ensure this treatment is appropriate and to customize your formula for your skin.
What to Expect
Week 1–2: Skin may feel drier or more sensitive as your routine adjusts; hydration and gentle support are key.
Weeks 2–4: Texture and clogged pores often start to look improved with consistent use.
Weeks 8–12: Fine lines, tone, and overall smoothness typically show more noticeable change with steady routine and sunscreen.
Why It Works
Tretinoin works at the cellular level to support skin renewal—helping improve the look of fine lines, sun damage, uneven tone, and breakouts while supporting firmer-looking skin over time.
Azelaic acid works alongside it by calming the pigment-making process behind dark spots and soothing visible redness, so tone evens out while tretinoin rebuilds texture.
How To Use
- Morning — 21AA azelaic acid: apply a thin layer to clean, dry skin, then moisturizer and SPF 30+.
- Night — Collagen Constructor: start 2–3 nights a week with a pea-sized amount on dry skin, then increase as tolerated. Follow with moisturizer.
- Wear sunscreen every day. Always follow the provider instructions included with your products.
Hear Why UluRx Clients Love Their Treatments
Trusted. Proven. Loved by customers nationwide.
“Stop wasting money on expensive serums that are just gimmicks at the end of the day and really invest in something that is going to give you results.”
“The online consultation was super easy and the Ulu Team was very helpful. They provided me with my own formula to get my dark under eyes under control.”
“I am in my sixties and I am glowing!”
“Thanks for all the great gifts you included in the box. You go above and beyond!”
“The anti-aging products are top notch and great for all ethnicities. My skin has never looked better.”
“The service and products here are unmatched.”
“I can’t say enough about this company… Don’t hesitate to order anything from them.”
“Thrilled Beyond Words! Thanks to UluRX, I am ecstatic with my results.”
“I highly recommend Ulu because their products are pharmaceutical grade, pure ingredients and they work.”
Why Custom Beats Drug-Store Every Time
Why Your Skin Will Feel (And Show) The Difference
Prescription strength — tretinoin is the active form of vitamin A. Retinol has to convert to it in your skin first, and head-to-head studies show retinol is several times weaker.
Direct collagen stimulation — activates fibroblasts for firmer, bouncier skin.
Deeper cellular turnover — clears texture, clogged pores, and dullness faster.
Treats advanced concerns — including stubborn wrinkles, sun damage, and hyperpigmentation.
Prescription customization — tailored irritation profile, strength, and base.
Results you can track — smoother texture in 2–4 weeks; softer fine lines and more even tone at 8–12 weeks of nightly use.
Frequently Asked Questions
Have questions? We’ve got answers. Here’s a collection of the most common questions we hear. If you don’t find what you’re looking for, feel free to reach out.
Yes. They are commonly paired: azelaic acid in the morning for tone and redness, tretinoin at night for texture and fine lines. Your provider reviews your questionnaire and confirms the routine and tretinoin strength that fit your skin. If you are pregnant or breastfeeding, do not use tretinoin.
The best tretinoin cream is prescription-strength, properly dosed, and paired with a routine that supports tolerability (hydration + daily SPF). UluRx Tretinoin Collagen Constructor includes an online prescription review and can be customized after checkout—so your provider can tailor the formula (and supportive ingredients) to your goals like fine lines, sun damage, texture, or breakouts.
No. Retinol is an over-the-counter vitamin A derivative that must convert in skin; tretinoin is prescription-strength retinoic acid and is generally more potent.
Yes—tretinoin is commonly used to help unclog pores and reduce acne breakouts while also improving visible signs of aging.
Many people notice early changes in texture first, with more visible improvements in tone and fine lines with consistent use over time. Consistency + SPF matter.
As skin adjusts to faster renewal, temporary dryness, sensitivity, or flaking can happen—especially if starting too often. Starting slowly and supporting the barrier helps.
Yes—your provider selects ingredients based on your concerns and preferences after checkout, and the formula may include multiple compatible ingredients in one bottle.
No. Tretinoin is not recommended during pregnancy or while trying to conceive. If you are pregnant, planning pregnancy, or breastfeeding, it’s important to disclose this during the post-checkout questionnaire so your provider can recommend a safer alternative.
Topical tretinoin is generally avoided during breastfeeding unless a provider determines it’s appropriate. Always disclose breastfeeding status after checkout so your provider can guide safe options.
Yes. Tretinoin is the prescription-strength form of vitamin A that has been widely studied for skin renewal, acne, and visible signs of aging.
Some people experience an initial adjustment phase where breakouts or flaking temporarily increase. This is commonly referred to as “purging” and typically improves as the skin adapts. Starting slowly and using supportive ingredients can help minimize discomfort.
Most people begin 2–3 nights per week, then gradually increase as tolerated. Your provider may adjust frequency or formulation based on your skin type, sensitivity, and goals.
Yes, but these areas are often more sensitive. Providers may recommend lower strength or added supportive ingredients when using tretinoin beyond the face.
Yes. Daily sunscreen is essential when using tretinoin. Tretinoin increases skin sensitivity to sunlight, and sunscreen helps protect results and reduce irritation.
Yes, but layering matters. Some actives are compatible, while others may increase irritation if combined incorrectly. UluRx providers customize formulas after checkout to ensure ingredients are paired appropriately.
Prescription tretinoin does not require conversion in the skin and is generally more potent and predictable than over-the-counter retinol products. It’s best used under provider guidance to balance effectiveness with tolerability.
Yes. Tretinoin is commonly used to address both acne and visible signs of aging, making it a versatile option for people dealing with breakouts, clogged pores, and fine lines simultaneously.
You check out normally, then complete the post-purchase prescription step if needed. A U.S.-licensed provider reviews and writes the prescription (often 1–3 business days), your formula is compounded (2–4 business days), then shipped to you with tracking.