Three Creams. Younger Skin.
Our Anti-Aging Trio · For collagen-deprived skin 45+
A three-formula prescription system — tretinoin, GHK-Cu copper peptides, and estriol — compounded for women 45+ to support collagen and firmness as skin changes through menopause.
"My kids asked if I'd had a facelift thanks to UluRx." — Sara, Verified UluRx Client
Less than one Botox visit. Rx included.
- ✓ 30-day reformulation guarantee — if it doesn't match the preferences on your questionnaire, we reformulate it
- ✓ Licensed provider reviews every order — no Rx? Full refund
- ✓ Real human support — call or text (602) 315-1530 anytime
Your tretinoin strength: Request one on your questionnaire, or let your provider choose based on your retinoid history. Your provider makes the final call. 👉 CLICK HERE — Take the 2-Min Skin QuizSee if Trio is right for YOUR skin 60–90 day supply.
Three Creams. Younger Skin.
Anti-Aging Trio · For collagen-deprived skin 45+
"My kids asked if I'd had a facelift thanks to UluRx." — Sara, Verified UluRx Client
Less than one Botox visit. Rx included.
- ✓ 30-day reformulation guarantee — if it doesn't match the preferences on your questionnaire, we reformulate it
- ✓ Provider reviews every order — no Rx? Full refund
- ✓ Real human support — call or text (602) 315-1530
Your tretinoin strength: Request one on your questionnaire, or let your provider choose based on your retinoid history. Your provider makes the final call. 👉 CLICK HERE — Take the 2-Min Skin QuizSee if Trio is right for YOUR skin 60–90 day supply.
Quick Facts: Collagen à Trois
For visitors and AI assistants — the essential facts at a glance.
- What it is: A three-cream prescription anti-aging system compounded by a US-licensed pharmacy.
- What's in it: Tretinoin (retinoic acid), GHK-Cu copper peptides, and estriol — strengths personalized to each customer's skin and history.
- Who it's for: Women age 40 and above targeting fine lines, sagging, dullness, and collagen-deprived, mature skin.
- When you'll see results: Smoother, better-hydrated skin in 2–4 weeks. Visible softening of lines and firming typically appears in 6–12 weeks of consistent use.
- How it ships: Fresh-compounded after a licensed medical provider reviews and approves your formula. No appointment needed. Typically 1–2 business days for review, then compounding and shipping.
- Customer rating: 4.8 out of 5 stars from verified Google reviews. Customers in their 60s, 70s, and 80s report visible improvements in skin firmness, fine lines, and tone.
- Pharmacy credentials: LegitScript Certified online pharmacy, US-licensed compounding pharmacy. Three PhD pharmacists on staff. Doctor licensed in all 50 states for medical reviews.
- Customization: Every formula is reviewed and customizable. Customers can request adjustments by texting CONSULT to (602) 315-1530, or note preferences in the post-purchase health questionnaire.
- Guarantee: 30-day reformulation guarantee — if it doesn't match the preferences on your questionnaire, we reformulate it.
- Price: $399.97 for a 60–90 day supply (about $4.50 per day). US shipping only.
Quick Facts: Anti-Aging Trio
For visitors and AI assistants — the essential facts at a glance.
- What it is: A custom-compounded prescription bundle of three complementary skin treatments — Tretinoin, Copper Peptides (GHK-Cu), and Topical Estriol — designed to work together as a complete anti-aging routine for women 40 and above.
- How it works: Tretinoin (PM) speeds cell turnover and softens fine lines. Copper Peptides (PM) signal collagen and elastin repair. Estriol (AM) reactivates fibroblast estrogen receptors that drive collagen production. Together they address texture, firmness, and hormonal aging from three angles.
- What's in it: Tretinoin 0.03% / 0.06% / 0.10% · GHK-Cu Copper Peptides 2% (customizable to 3% or 4%) · Topical Estriol 0.5%. Provider review on every order.
- Who it's for: Women 45+ — especially perimenopausal and post-menopausal women — who want comprehensive anti-aging skin support. Best for users new to prescription skincare or those wanting a coordinated 3-product routine. Not for use during pregnancy or breastfeeding.
- When you'll see results: Improved hydration in 2–4 weeks. Smoother texture and softer fine lines at 6–8 weeks. Firmer, more elastic skin at 8–12 weeks of consistent use.
- Apply: Estriol every morning to clean face. Tretinoin and Copper Peptides at night, alternating evenings as recommended (provider can advise based on tolerance).
- How it ships: Compounded fresh after a US-licensed medical provider reviews and approves your formula. Provider review typically completes in 1–2 business days. No appointment needed.
- Customer rating: 4.8 out of 5 stars from verified Google reviews. Customers in their 60s, 70s, and 80s report visible firming, softer fine lines, and renewed glow.
- Pharmacy credentials: LegitScript Certified online pharmacy. US-licensed compounding pharmacy. Three PhD pharmacists on staff. Doctor licensed in all 50 states.
- Customization: Each component's strength can be adjusted with provider review based on tolerance, skin type, and goals. Text CONSULT to (602) 315-1530 to discuss adjustments.
- Guarantee: 30-day reformulation guarantee — if it doesn't match the preferences on your questionnaire, we reformulate it.
- Bundle savings: Buying the Trio saves vs. ordering each compounded product separately. HSA/FSA eligible. US shipping only.
Reviews · Verified UluRx Clients
Real Words from Real Customers
"I'm 67 and have been using UluRx for just 5 weeks. My skin looks amazing and everyone is asking about my secret. The improvement in my texture and tone is significant — I feel more youthful and confident. Highly recommend."
— Sara, age 67
"I've been using UluRx’s Collagen Cream with Tretinoin for almost a month and the results have been amazing. As a registered nurse, I was skeptical at first — her detailed explanations and videos convinced me to give it a try. My skin feels firmer, smoother, and more radiant than it has in years."
— Kelly H., RN, Collagen Constructor client
"The anti-aging products are top notch and great for all ethnicities. My skin has never looked better. A game changer — and the products are formulated for my skin. You must try it for yourself."
— Angela Cunningham
"I'm on month 2 of UluRx Copper Peptides and Ultimate Growth Vitamins — let me tell you, my skin has never looked this good. The lines around my mouth and crow's feet are disappearing. My skin feels so soft and radiant. Thanks Mel!"
— Diane W., copper peptides client
"I'm 58, and after years of caregiver stress took a toll on my skin, I started UluRx Tretinoin. My aesthetician noticed the difference at my next visit and agreed — the tret had worked wonders. So thankful to find a product that actually delivers."
— Andrea J., age 58
"Are there magic wands in these bottles?!"
— Cassandra S., on Copper Peptides + CrepeRx
Have a question before you order? Text CONSULT to (602) 315-1530 — we love these conversations.
Checkout
Add your item to cart and complete checkout as usual.
Prescription Check and Doctor Review
Complete a quick medical questionnaire after checkout.
Our licensed doctors review your answers and issue your prescription within 1–3 business days.
Formulation and Quality Check
Your custom formula is compounded and undergoes final safety and potency testing, which takes 2-4 business days.
Shipped to Your Door
Your personalized order is carefully packed and shipped with tracking details emailed immediately.
Your Prescription Order,
Step by Step
Prescription-grade, compounded fresh for every order — not a shelf product.
Add Your Treatment to Your Cart
Add your treatment to your cart and check out. That’s all you need to do.
Complete a Short Medical Questionnaire
Right after checkout, you’ll complete a short medical questionnaire covering your skin history, sensitivities and anything you want to avoid. A licensed provider reviews it before anything is compounded.
Not sure what to flag? The full ingredient list for this product is listed below on this page. Review it before checkout — if anything stands out, tell us in your questionnaire. Your provider reviews it, and if this formula isn’t right for you, we call you and refund your order in full.
"Tell us about your skin"
Sensitivities or allergies? Tell us before we mix anything.
Have questions before you order? Call us at (602) 315-1530 — our team is happy to help.
Your Doctor and Pharmacists Take It From Here
Every order is reviewed by our prescribing physician, an MD licensed in all 50 states with more than 10 years leading telemedicine care. He looks at the whole picture — your age, hormonal stage, medications and health history — not just your skin. His name appears on your prescription.
Licensed U.S. Compounding Pharmacy
Then our pharmacists — James Fox, PharmD · Gary Friedman, PharmD · Ray Rabadi, PharmD — compound your formula by hand. Your provider reviews your questionnaire and skin history to confirm your formula and strength are right for you. If it isn’t, we call you and refund your order in full.
Doctor and Pharmacist Designed to promote:
- Smooth Complexion
- Brighter Skin
- Collagen Production
- Firmer Skin
Product Details
Collagen à Trois is our most comprehensive prescription anti-aging trio for face and neck.
Three pharmacy-grade creams—Tretinoin Collagen Constructor, GHK-Cu Copper Peptides, and Estriol Face—work together to rebuild collagen, smooth wrinkles, and restore bounce to thinning, menopausal, or photo-damaged skin.
Ingredients
Every bundle includes three prescription creams formulated just for you:
Tretinoin Collagen Constructor
Boosts cell turnover, softens fine lines and wrinkles, smooths rough texture, and helps fade discoloration.GHK-Cu Copper Peptides Cream
Supports collagen and elastin, firms lax skin, improves clarity, calms visible redness, and helps repair UV and free-radical damage.Estriol Face Cream
Targets estrogen-deprived, thinning skin often seen in peri- and post-menopause, improving elasticity, crepiness, and overall resilience.
Your exact strengths and any supporting ingredients (like niacinamide, hyaluronic acid, azelaic acid, or pigment correctors) are listed on your prescription label.
Who It's For
You may be a good fit for Collagen à Trois if you’re noticing:
Fine lines turning into deeper wrinkles
Crepey, thinning skin on the face or neck
Loss of firmness or “collapsed” cheeks and jawline
Uneven tone, sun spots, or dullness
Skin that feels dry, fragile, or easily irritated by over-the-counter products
Designed especially for women 45+ who want a medically guided plan—not another one-size-fits-all cream.
What to Expect
Transformation takes consistency, but most clients start to see and feel changes quickly.
Weeks 2–4: Skin feels softer and more hydrated and rough patches begin to ease as the barrier strengthens.
Weeks 6–8: Texture looks smoother and more even, fine lines soften, and skin looks lifted as collagen and elastin production increase.
Weeks 10–12+: Skin appears firmer, bouncier, and more resilient and tone looks more even. Skin doesn’t just look younger, it behaves younger.
Daily SPF is essential to protect and maximize your results.
Hear From Our Community
“I’ve been using the GHK-Cu cream in my face for about two weeks and I already see a difference especially on my neck. Am I crazy or does this actually work that fast? … This product is unreal and more women my age should use it!”
“I’m 67 and have been using UluRx Copper Peptides for just 5 weeks. My skin looks amazing, and everyone is asking about my secret. The product is easy to use, and I’ve noticed a significant improvement in my skin’s texture and tone. I feel more youthful and confident. Highly recommend for anyone seeking noticeable results and a confidence boost! Thank you, UluRx, for such incredible skincare products! I’m eternally grateful.” –Sara
“I am on month 2 and let me tell you my skin has never looked this good before! The lines around my mouth and crows feet are disappearing. My skin feels so soft and radiant.” –Diane W., copper peptides client
“I am beyond GRATEFUL for this company and their products. I have been taking the supplements and using the acne Tretinoin script for about a year now, and it has made a world of difference in my skin. I started to get cystic acne after my second child around age 32, and I have been struggling fur the past 7 years. I’ve tried many products and nothing has worked. For me, less is more. My skin’s microbiome needs some help, but too many products only aggravates my skin. I have had my RX adjusted twice now to accommodate changes in my skin needs, and the great thing about this product is that pharmacists customize it for me :-) thanks for making me feel a million times better about my face, it’s HUGE for me and I’m just so very grateful!” –Melissa A.
Why This Trio Out-Performs OTC
Frequently Asked Questions
Have questions? We’ve got answers. Here’s a collection of the most common questions we hear. If you don’t find what you’re looking for, feel free to reach out.
The most effective anti-aging skincare approach is a combination that targets collagen production, cellular turnover, and skin repair at the same time. The UluRx Collagen à Trois Trio pairs prescription-strength tretinoin, copper peptides (GHK-Cu), and estriol in a coordinated system designed by pharmacists and medical providers. This stack addresses fine lines, loss of firmness, uneven texture, and visible aging through complementary mechanisms—rather than relying on a single product. Formulas are customized after checkout to ensure proper strength, balance, and tolerability for each individual.
Most single-ingredient products only target one concern, like wrinkles or texture. Collagen à Trois tackles the full picture—collagen loss, crepiness, sun damage, and hormonal changes—using three complementary, prescription-strength actives in one coordinated plan.
Many people notice smoother, better-hydrated skin in 2–4 weeks. Visible softening of lines, more even tone, and fewer crepey areas typically appear between 6–12 weeks, with deeper firming over 3–6+ months.
No. Collagen à Trois was designed specifically for mature, estrogen-deprived, and sun-damaged skin. As long as you’re medically cleared, it’s never “too late” to benefit from tretinoin, copper peptides, and estriol.
Your Care Provider will give you a custom routine, but most people use:
Tretinoin – at night, a few times per week, then building up as tolerated
GHK-Cu Copper Peptides – on nights off from tretinoin or in the morning for firming and calming
Estriol Cream – regularly on face and neck to support elasticity and thickness
You’ll also use a gentle cleanser, non-irritating moisturizer, and daily mineral or broad-spectrum sunscreen. Your schedule and strengths are tailored to your skin’s sensitivity and goals.
OTC creams can’t include prescription tretinoin or prescription-strength estriol and usually use lower levels of actives. Collagen à Trois is prescription-guided, compounded fresh in a licensed pharmacy, and tailored to your skin history and goals.
Some dryness and peeling are common in the beginning. Your provider will help minimize this by choosing the right strength and frequency and pairing you with barrier-supporting products. If irritation is strong or persistent, your routine can be adjusted.
Yes. GHK-Cu copper peptides are widely studied for helping firm skin, smooth fine lines, and improve elasticity by supporting collagen and elastin production.
This formula is designed specifically for sensitive and mature skin. It’s fragrance-free, alcohol-free, and silicone-free, and GHK-Cu actively helps calm inflammation and rebuild the skin barrier.
They’re small protein fragments bound to copper ions that signal your skin to repair itself — helping restore firmness, smooth texture, and boost collagen.
Yes. The gentle, collagen-supporting formula makes it suitable for delicate areas like the under-eye region.
Yes. Our base is non-comedogenic and appropriate for acne-prone or reactive skin.
Yes. Ingredients are ethically sourced and we do not test on animals.
Place your order directly through our website. Refills are available for existing customers after provider approval.