Drugstore vs Prescription Crepey Skin Cream

The difference is the science. Drugstore crepey skin lotions use retinols, which your skin has to convert into retinoic acid with its own enzymes. If you don’t have enough of those enzymes, you won’t see collagen-building results. Prescription tretinoin is already retinoic acid, so it skips that step.

The prescription option

CrepeRx is a prescription tretinoin 0.11% body cream with hyaluronic acid and niacinamide, made for crepey skin on the arms, legs and chest.

Do I need a prescription?

Yes, and it’s included. After checkout, you answer a short questionnaire. A licensed medical provider reviews it, typically within 1–3 business days. If the provider doesn’t approve CrepeRx for you, we refund the CrepeRx part of your order.

Video transcript

Drugstore lotion versus a prescription-strength crepey skin product: the difference is the science. What they don’t tell you on this packaging is that if you do not have the enzymes to convert these retinols to retinoic acid, you will not see any collagen-building results. Prescription strength builds collagen.

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